Amboy is an unincorporated community in San Bernardino County, in California's Mojave Desert, west of Needles and east of Ludlow on historic Route 66. It is roughly 60 miles northeast of Twentynine Palms. As of 2020, the town's business district still contained a post office, a historic restaurant-motel, and a Route 66 tourist shop, all operated by the town's populace of 4 people.