Cristóbal de Mondragón y Mercado was a Spanish general during the Eighty Years' War.
He was a prominent military figure of the sixteenth century, and was colonel of one of the Tercios of Flanders under the Duke of Alva, Luis de Requesens, Alexander Farnese and Count Mansfeld. He fought during the Eighty Years' War against the armies of William of Orange first and after Maurice of Nassau.
His talent as a strategist led to important victories by the Spanish troops in Flanders and the Netherlands in a time of decline of Spanish domination in this region.
Mondragón developed several military techniques like wading through tidal rivers and espionage.