Gabrielle Réjane, née Gabrielle Charlotte Réju, was a French actress of the late 19th and early 20th centuries.
The daughter of a former actor, Réjane studied at the Paris Conservatoire and made her stage debut in 1875. After eight seasons at the Théâtre du Vaudeville in increasingly prominent roles, she became leading lady at the Théâtre des Variétés, a position she combined with appearances in more substantial plays at other theatres. She became known chiefly for her roles in comedies, but made an impression in serious character parts from time to time. Her biggest success was as Catherine, the outspoken washerwoman who becomes a duchess in the historical comedy-drama Madame Sans-Gêne by Sardou and Moreau. She created the role in 1893 and played it frequently for much of her career. Among her other celebrated roles was Nora in Henrik Ibsen's A Doll's House in 1894, which gave the author his first success in France.
Réjane appeared in major cities throughout Europe, and was particularly popular in London, where she played frequently between 1877 and 1915. She twice played on Broadway, but did not become popular with American audiences.