The Garden Route National Park is a national park in the Garden Route region of the Western Cape and Eastern Cape provinces in South Africa. It is a coastal reserve well known for its indigenous forests, dramatic coastline, and the Otter Trail. It was established on 6 March 2009 by amalgamating the existing Tsitsikamma and Wilderness National Parks, the Knysna National Lake Area, and various other areas of state-owned land.
The park covers about 1,210 km² of land; of this, about 685 km² was already part of the predecessor national parks. The park includes a continuous complex of approximately 605 km² of indigenous forest.
The Garden Route National Park has a pleasant, temperate climate; it is unique in Africa as the only area in which rainfall occurs throughout the year.