Guaratinguetá is a municipality in the state of São Paulo in Brazil. It is part of the Metropolitan Region of Vale do Paraíba e Litoral Norte. The population is 122,505 in an area of 752.64 km². It is located in the region of Vale do Paraíba; prominent individuals from the area include Saint Frei Galvão, Brazilian President Rodrigues Alves and the cardiologist Dr Euryclides de Jesus Zerbini. The name of the city derives from the words in the Tupi language: gûyra, tinga and etá, resulting in Gûyrating'etá.
The municipality contains part of the 292,000 hectares Mananciais do Rio Paraíba do Sul Environmental Protection Area, created in 1982 to protect the sources of the Paraíba do Sul river.