Heroica Ciudad de Huajuapan de León is a city with a surrounding municipality located in the northwestern part of the Mexican state of Oaxaca.
It is part of the Huajuapan District in the north of the Mixteca Region.
It has a population of about 45,321, the sixth-largest community in the state in population. It is located at the intersection of Federal Highways 125 and 190. The name of Huajuapan comes from the Nahuatl words huaxin = huaje, ohtli = road, and apan = river. Literally, River of the huajes. The town was elevated to an honorary Mexican status in June 1843 in remembrance of The siege of Huajuapan, a battle between the royal army and the insurgents led by José María Morelos. The battle was won by the insurgents. The city was named after Antonio de León, a hero of the Mexican War of Independence.