Kruiningen is a village in the Dutch province of Zeeland. It is located in the municipality of Reimerswaal, about 5 km south of the village of Yerseke.
Kruiningen has a station on the railway line Bergen op Zoom - Vlissingen.
Kruiningen achieved some notoriety as departure and arrival of the ferry Kruiningen-Perkpolder. In 2003, this ferry closed in connection with the opening of the Westerscheldetunnel.