Villanueva de Sigena or Villanueva de Sijena is a town in the county of Los Monegros, in the northern province of Huesca, in Aragon. Located near the Alcanadre river, the local economy is primarily agricultural-based.
The Royal Monastery of Santa María de Sigena is located on the outskirts of town. Mount Sigena is a hill of the Sierra de Alcubierre located 5 km to the south.
Villanueva de Sigena is the birthplace of the physician and heterodox theologian, Michael Servetus. Servetus was the discoverer of pulmonary circulation. A museum and interpretation center, maintained by the Michael Servetus Institute, is now located in the original house were Servetus was born.
Nearby there is the original settlement, based round the partially ruined, and once wealthy and aristocratic Romanesque convent of Santa María la Real de Sijena, founded in 1183 by Sancha of Castile, Queen of Aragon. This was largely destroyed by fire in 1936 by anti-clerical Republicans in the Spanish Civil War. It is now in the process of restoration, and has been reoccupied by nuns since 1985.