Samuel Marvin Griffin, Sr. was an American politician from the U.S. state of Georgia.
A lifelong Democrat, Griffin was a native of Bainbridge, Georgia and publisher of the Bainbridge Post-Searchlight. He served as the 72nd Governor of Georgia from 1955 to 1959, where he supported educational segregation and opposed the integration of Georgia schools. After the end of his gubernatorial tenure, he returned to his native Bainbridge and entered the real estate business, helping to found Bainbridge College in 1970. He served on the college's board of directors and died from lung cancer in 1982.