Pope Adrian VI, born Adriaan Florensz Boeyens, was head of the Catholic Church and ruler of the Papal States from 9 January 1522 until his death on 14 September 1523. The only Dutchman to become pope, he was the last non-Italian pope until Polish John Paul II 455 years later.
Born in the Episcopal principality of Utrecht, Adrian studied at the University of Leuven in the Low Countries, where he rose to the position of professor of theology, also serving as rector. In 1507, he became the tutor of the future Holy Roman Emperor Charles V, who later trusted him as both his emissary and his regent.
In 1516, Charles, now King of Castile and Aragon, appointed Adrian bishop of Tortosa, Spain, and soon thereafter Grand Inquisitor of the kingdoms of Aragon and Castile. Pope Leo X made him a cardinal in 1517 and after Leo's death he was elected pope in 1522 as a compromise candidate.
Adrian came to the papacy in the midst of one of its greatest crises, threatened not only by Lutheranism to the north but also by the advance of the Ottoman Turks to the east. He refused to compromise with Lutheranism theologically, demanding Luther's condemnation as a heretic.