Salina Cruz is a major seaport on the Pacific coast of the Mexican state of Oaxaca. It is the state's third-largest city and is the municipal seat of the municipality of the same name.
It is part of the Tehuantepec District in the west of the Istmo Region.
The city had a 2005 census population of 71,314, while its municipality, with an area of 113.55 km² had a population of 76,219, the state's fourth-largest municipality in population.
The port was developed in the late 19th century due to its location at the southern terminus of the Ferrocarril Transístmico, which carried freight across the Isthmus of Tehuantepec.