Sansepolcro, formerly Borgo Santo Sepolcro, is a town and comune founded in the 11th century, located in the Italian Province of Arezzo in the eastern part of the region of Tuscany.
Situated on the upper reaches of the Tiber river, the town is the birthplace of the painters Piero della Francesca, Raffaellino del Colle, Santi di Tito and Angiolo Tricca. It was also the birthplace of the Italian mathematician Luca Pacioli, and of Matteo Cioni, who translated Piero della Francesca's treatise about perspective in painting into Latin.
Today, the economy of the town is based on agriculture, industrial manufacturing, food processing and pharmaceuticals. It is the home of Buitoni pasta, founded by Giulia Buitoni in 1827.