Sesto al Reghena is a comune in the Province of Pordenone in the Italian region Friuli-Venezia Giulia, located in the lower Friulian-Venetian plain about 80 kilometres northwest of Trieste and about 20 kilometres southeast of Pordenone.
Sesto al Reghena borders the following municipalities: Chions, Cinto Caomaggiore, Cordovado, Gruaro, Morsano al Tagliamento, San Vito al Tagliamento.