Sperone Westwater is a contemporary art gallery in the Bowery, in Manhattan, in New York City. The partners are Angela Westwater and Gian Enzo Sperone. The gallery was started on Greene Street in Soho in 1975; the first show was of work by Carl André. Since 2010 it has occupied a building on Bowery purpose-built to designs by Foster + Partners.
In 2008 the gallery inaugurated a second venue at Chasa dal Guvernatur in Sent, Switzerland, with an exhibition of Bruce Nauman.