Pascagoula is a city in Jackson County, Mississippi, United States. It is the principal city of the Pascagoula Metropolitan Statistical Area, and is part of the Gulfport–Biloxi–Pascagoula Combined Statistical Area. The population was 22,392 at the 2010 census, down from 26,200 at the 2000 census. As of 2019 the estimated population was 21,699. It is the county seat of Jackson County.
The city is served by three airports: Mobile Regional Airport, 34 miles to the northeast in Alabama; Gulfport-Biloxi International Airport, about 40 miles west of Pascagoula; and the Trent Lott International Airport, 9 miles to the north in Jackson County.
The current mayor of the city is Steve Demetropoulos.