Rome is a city in Oneida County, New York, United States, located in the central part of the state. The population was 33,725 at the 2010 census. Rome is one of two principal cities in the Utica–Rome Metropolitan Statistical Area, which lies in the "Leatherstocking Country" made famous by James Fenimore Cooper's Leatherstocking Tales, set in frontier days before the American Revolutionary War. Rome is in New York's 22nd congressional district.
The city developed at an ancient portage site of Native Americans, including the historic Iroquois nations. This portage continued to be strategically important to Europeans, who also used the main 18th and 19th-century waterways, based on the Mohawk and Hudson rivers, that connected New York City and the Atlantic seaboard to the Great Lakes. The original European settlements developed around fortifications erected in the 1750s to defend the waterway, in particular the British Fort Stanwix built in New York.
Following the American Revolution, the settlement began to grow with the construction of the Rome Canal in 1796, to connect Wood Creek and the headwaters of the Mohawk River.