Marino Caracciolo was a Neapolitan cardinal and diplomat in the service of Emperor Charles V.
Born in Naples into one of the most important families in the Kingdom of Naples, he spent his youth and was educated under the tutelage of Cardinal Ascanio Sforza at the court of Milan. Ambassador of Duke Massimiliano Sforza to the Papal court in 1513 he was created an Apostolic Protonotary in 1515; in the same year he took part as orator of the Duke of Milan to the V Lateran Council.
In 1518 he was appointed Papal Nuncio to Spain and in 1519 Nuncio before the Diet of Augsburg. At the Diet of Worms in 1520 he worked with Cardinal Girolamo Aleandro against Martin Luther.
After the election of Emperor Charles V he entered into his service and was ambassador to England and to Venice. In 1524 he was created Bishop of Catania, but resigned three times in favour of other members of his family. In the same year he was enfeoffed with large estates in the Duchy of Milan. He was created a Cardinal of the Holy Roman Church by Pope Paul III on 21 May 1535, but his name was not announced publicly.