The Palazzo Massimo alle Colonne is a Renaissance palace in Rome, Italy. The palace was designed by Baldassarre Peruzzi in 1532–1536 on a site of three contiguous palaces owned by the old Roman Massimo family and built after arson destroyed the earlier structures during the Sack of Rome. In addition the curved facade was dictated by foundations built upon the stands for the stadium of the emperor Domitian. It fronts the now-busy Corso Vittorio Emanuele II, a few hundred yards from the front of the church of Sant'Andrea della Valle.
The entrance is characterized by a central portico with six Doric columns, paired and single. Inside there are two courtyards, of which the first one has a portico with Doric columns as a basement for a rich loggia, which is also made of Doric columns. The column decorations gave the name to the palace, alle Colonne. The facade is renowned as one of the most masterful of its time, combining both elegance with stern rustication. The recessed entrance portico differs from typical palazzo models such as exemplified by the Florentine Palazzo Medici.