Polidoro de Rienzo da Lanciano was an Italian painter.
Relatively little is known of his life. He was born in Lanciano, a town that is a few miles inland from Ortona, a port on the Adriatic Sea. This is in the Abruzzi region of Italy, lying southeast of Pescara. His grandfather, Alessandro Rienzo, was a ceramic painter in Lanciano. Based on Venetian documents Polydoro's birthdate is taken to be 1515. At an early age he apparently showed great artistic talent. and for that reason he moved to Venice, the center of art in that region of Italy, at a young age. There he assumed a Venetian form for his name, Lanzani. His first mention in official Venetian documents is 1536, when he would have been 21 years of age. He probably came to Venice at least five years prior to that in order to begin his artistic training. His name appears as a witness to a document in the years 1536 and 1549. His Last Will and Testament bears his signature, and is dated 20 July 1565. He died the following day, with his age reported as 50. He likely worked as an assistant to Titian for many years, especially given the close resemblance of his style with that of the Venetian master.