Salisbury is a city in and the county seat of Wicomico County, Maryland, United States, and the largest city in the state's Eastern Shore region. The population was 30,343 at the 2010 census. Salisbury is the principal city of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The city is the commercial hub of the Delmarva Peninsula, which was long devoted to agriculture and had a southern culture. It calls itself "The Comfortable Side of Coastal".