Shashamane is a town in West Arsi Zone, Oromia Region, Ethiopia. The town lies on the Trans-African Highway 4 Cairo-Cape Town, about 150 miles from the capital of Addis Ababa. It has a latitude of 7° 12' north and a longitude of 38° 36' east.
The 2007 national census reported a total population for this town of 100,454, of whom 50,654 were men and 49,800 were women. A plurality of the inhabitants practiced Ethiopian Orthodox Christianity, with 43.44% of the population reporting they observed this belief, while 31.15% of the population said they were Muslim, 23.53% of the population were Protestant, and 1.3% were Catholic.
The 1994 national census reported the town had a total population of 52,080, 25,426 of whom were males and 26,654 were females.
The resort of Wondo Genet lies near Shashamane, as does the Senkele Wildlife Sanctuary.