The Shirley–Eustis House is a historic house located at 33 Shirley Street, Boston, Massachusetts. It is a U.S. National Historic Landmark.
The house was built between 1747 and 1751 on 33 acres in Roxbury by William Shirley, Royal Governor of the Province of Massachusetts Bay, and served as his summer home. The house is attributed to architect Peter Harrison, and built in part by Thomas Dawes, it is one of four remaining mansions of Royal Governors in the United States.
In 1763 Shirley's son-in-law Eliakim Hutchinson, Chief Justice of the Court of Common Pleas for Suffolk County, and one of Boston's richest men, acquired the house from his father-in-law. Upon retirement from his post as Governor of the Bahamas in 1769, William Shirley moved in with his daughter and son-in-law and lived there until his death in 1771.
After Hutchinson died in 1775, the house was occupied by Colonel Asa Whitcomb's Massachusetts Sixth Foot Regiment, and in 1778 it was seized as Loyalist property.