According to Herodotus, Sisamnes was a corrupt judge under Cambyses II of Persia. He accepted a bribe and delivered an unjust verdict. As a result, the king had him arrested and flayed alive. His skin was then used to cover the seat in which his son would sit in judgment.
Sisamnes was the subject of two paintings by Gerard David, "The Arrest of Sisamnes" and "Flaying of Sisamnes" both done in 1498. Together they make up The Judgement of Cambyses diptych, which was commissioned to hang in the Aldermen's Room in the Bruges City Hall. Sisamnes is also the subject of two paintings, one by Dirk Vellert, and the other by Peter Paul Rubens
Sisamnes had a son named Otanes who replaced him as a judge, and later became a Satrap in Ionia.