Tepelenë is a city and a municipality in Gjirokastër County, in the south of Albania. The town is located on the left bank of the Vjosa River, about three kilometres downstream from its union with the Drino.
Until the abolition of Districts in 2000, Tepelenë was the seat of the Tepelenë District. Its location is strategically important and there is a ruined citadel occupying a point 300 metres above the river. Ali Pasha of Tepelenë was born at the nearby village of Beçisht. In 1847, the British writer Edward Lear visited the town and noted the devastated buildings.