Titusville is a city in the far east corner of Crawford County, Pennsylvania, United States. The population was 5,601 at the 2010 census and an estimated 5,158 in 2019. Titusville is known as the birthplace of the American oil industry and for a number of years was the leading oil-producing region in the world. Titusville was notable for its lumber industry, including 17 sawmills, as well as its plastic and toolmaking industries.