Ugolino di Nerio was an Italian painter active in his native city of Siena and in Florence between the years 1317 and 1327.
He was a follower of Duccio di Buoninsegna, from whose Maestà some of his scenes are clearly derived. He was a leading master who contributed to the spread of Sienese painting in Florence by earning commissions to paint in the two main basilicas there, Santa Maria Novella and Santa Croce.