Urbino is a walled city in the Marche region of Italy, south-west of Pesaro, a World Heritage Site notable for a remarkable historical legacy of independent Renaissance culture, especially under the patronage of Federico da Montefeltro, duke of Urbino from 1444 to 1482. The town, nestled on a high sloping hillside, retains much of its picturesque medieval aspect. It hosts the University of Urbino, founded in 1506, and is the seat of the Archbishop of Urbino. Its best-known architectural piece is the Palazzo Ducale, rebuilt by Luciano Laurana.