Wellsville is a village in Columbiana County, Ohio, United States, along the Ohio River. Its population was 3,541 at the 2010 census. Wellsville is the southernmost point of the Salem, OH Micropolitan Statistical Area, as well as the greater Mahoning Valley, although it is more connected to the Upper Ohio Valley. In its heyday, Wellsville was home to industries in transportation, both through rail terminals on the Pennsylvania Railroad and docks on the Ohio River, as well as pottery and ceramics manufacturing.