Wise is a town in Wise County, Virginia, United States. The population was 3,286 at the 2010 census. It is the county seat of Wise County. It was originally incorporated as the town of Gladeville in 1874. The town's name was changed to Wise in 1924. Wise is named after Henry A. Wise, the last Virginia governor before the American Civil War and the first governor to hail from the Eastern Shore of Virginia.
The town is also the home of the University of Virginia's College at Wise.