Witherspoon Building is a historic office building located in the Market East neighborhood of Philadelphia, Pennsylvania. It was designed by architect Joseph M. Huston and built between 1895 and 1897. It was built for the Presbyterian Board of Publications and Sabbath School Work. It is an 11-story, steel frame "E"-shaped building, faced with brick and granite. It has terra cotta decorative elements. Its exterior features Corinthian order and Ionic order columns, statues, medallions, seals of various boards and agencies of the Presbyterian Church and of related Reformed churches. It is named for John Witherspoon, a president of Princeton University.
It was added to the National Register of Historic Places in 1978.