This page of Vesalius' De humani corporis fabrica libri septem (On the fabric of the human body in seven books) is one of the best known illustrations from the Fabrica.
The paints used by the first owner, German physician Caspar Neefe to colour many of the illustrations in this copy of the Fabrica would have been made from the pigments available at the time, such as lapis-lazuli, azurite, malachite, calcite, and umber.
The Fabrica is considered one of the most important medical books ever published, and changed the way that anatomy was understood and taught.