The painting depicts a group of plague victims in the foreground and, in the background on the left, the Doge Alvise Mocenigo with the senators on their knees facing Jesus Christ who appears at the top right. The quick and cursive drafting denounces that the canvas constituted the model for a great painting, whose original location remains undetected to this day. Assigned first to Jacopo Tintoretto when it was in the Bernasconi collection, then to Giacomo Palma il Giovane, it is now attributed to Andrea Vicentino.