Annotated page from Book 1 of the first edition of De humani corporis fabrica libri septem (On the fabric of the human body in seven books), with annotations and hand coloured imaged by German physician Caspar Neefe, the first owner of this copy of the book. This page is titled "Nomina quibus ossium par" (the names for bones).
The paints used by the first owner, German physician Caspar Neefe to colour the illustrations would have been made from the pigments available at the time, such as lapis-lazuli, azurite, malachite, calcite, and umber.
The Fabrica is considered one of the most important medical books ever published, and changed the way that anatomy was understood and taught.