Sermoneta is a hill town and comune in the province of Latina, central Italy.
It is a walled hill town, with a 13th-century Romanesque cathedral called Cathedral of Santa Maria Assunta and a massive castle, built by the Caetani family. The Cistercian Valvisciolo Abbey is located nearby. The churches of San Giuseppe and San Michele still stand.
In the 13th-16th centuries, it was home to a flourishing Jewish community.
Sermoneta is the hometown of the humanist Aldo Manuzio and the Baroque painter Antonio Cavallucci.
Scenes of the 2007 film Silk featuring Keira Knightley were filmed in Sermoneta.
The 2015 short film Italian Miracle was filmed in the town.
An episode of Return of the Saint was filmed there and the town was known as Santa Maria.